PHARMACOLOGICAL ACTIVITY OF EXTRACTS FROM PLANTS OF COSMOS BIPINNATUS CAV. SPECIES

The aim of the study is to determine antioxidant, anti-inflammatory and hypolipidemic activities extracts from Cosmos bipinnatus Cav. three varieties, obtained by extraction with 70% ethyl alcohol. Materials methods. antioxidant effect was studied in vitro using a model iron-induced lipid peroxidation lecithin liposome system. activity carried out on 30 male rats “Wistar” line. Diclofenac used as reference drug (p. o., dose 13 mg/kg terms weight an adult). substances were administered animals form aqueous suspension stabilized Tween-80. To simulate inflammatory process, “cotton granuloma” created. A 36 white extracts, tween create hyperlipidemic state rats, concentrations total cholesterol triglycerides determined serum experimental animals. Results. conducted experiments made it possible conclude that alcohol dried inflorescences “Dazzler”, “Rosea” “ Purity” varieties have kinds activities. It has been established “Dazzler” ( Cav.) contribute better reduction accumulation peroxide compounds, compared extract “Purity” variety. data analysis shows all objects significantly (p = 0.05) reduce stage exudation control group 50% (the « Purity» variety), 52% Rosea» variety) 40% “Dazzler ” variety). An experiment revealed significant, relation values intact group, increase level blood 78%, (TGCs) – 64%. administration , animals, led decrease 44%, 47%, 50%, 52%, 57%, respectively. Both indicators reached normal did not differ healthy (intact) Conclusion. According studies, can be concluded Cоsmos Cav ., pronounced effect.